解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Single molecule observation of fluorescence resonance energy transfer can be used to provide insight into the structure and dynamics of proteins. Using a straightforward triple-colour labelling strategy, we present a measurement and analysis scheme that can simultaneously study multiple regions within single intrinsic...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25135c
更新日期:2012-10-01 00:00:00
abstract::As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25099c
更新日期:2012-10-01 00:00:00
abstract::Recently, more and more research has shown that microRNAs (miRNAs) play critical roles in the development and progression of various diseases, but it is not easy to predict potential human miRNA-disease associations from the vast amount of biological data. Computational methods for predicting potential disease-miRNA a...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25180a
更新日期:2012-10-01 00:00:00
abstract::Although angiotensin (Ang)II-induced Janus-activated kinase (JAK)2 phosphorylation was reported to be enhanced in failing human cardiomyocytes, the downstream balance between cardio-protective (signal transducer and activator of transcription-STAT3) and the pro-inflammatory (STAT2 and STAT5) response remains unexplore...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25120e
更新日期:2012-09-01 00:00:00
abstract::Protein-protein interactions are important biological processes and essential for a global understanding of cell functions. To date, little is known about the protein interactions and roles of the protein interacting networks and protein complexes in bacterial resistance to antibiotics. In the present study, we invest...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25090j
更新日期:2012-09-01 00:00:00
abstract::Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by either stabilizing or de-stabilizing these rope-like polymers. Amon...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25144b
更新日期:2012-08-01 00:00:00
abstract::The importance of microRNA (miRNA) in modulating gene expression at the post-transcriptional level is well known. Such regulation has been shown to influence the dynamics of several regulatory networks including the cell cycle. In this study we incorporated regulatory effects of intronic miRNA into an existing mathema...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25046b
更新日期:2012-08-01 00:00:00
abstract::A rapid and sensitive gold-nanobioprobe based immunoassay format has been presented for the detection of capsular Vi polysaccharide of Salmonella enterica serovar Typhi (surface antigen) using anti-Vi antibodies. The Vi antigen was extracted from serovar Typhi cells, under the optimised growth conditions for its over-...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25048a
更新日期:2012-07-06 00:00:00
abstract::Nicotinamide adenine dinucleotide (NAD) is a ubiquitous cofactor participating in numerous redox reactions. It is also a substrate for regulatory modifications of proteins and nucleic acids via the addition of ADP-ribose moieties or removal of acyl groups by transfer to ADP-ribose. In this study, we use in-depth seque...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05487f
更新日期:2012-06-01 00:00:00
abstract::Upon rapid ascent to a high altitude, non-acclimatized individuals, although healthy, are highly prone to contracting high-altitude pulmonary edema (HAPE). Early diagnosis is difficult and there is no reliable biomarker available. We used proton ((1)H) NMR metabolomics to profile the altered metabolic patterns of bloo...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25044f
更新日期:2012-06-01 00:00:00
abstract::Climatic change is an increasing challenge for agriculture that is driving the development of suitable crops in order to ensure supply for both human nutrition and animal feed. In this context, it is increasingly important to understand the biochemical responses of cells to environmental cues at the whole system level...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25056j
更新日期:2012-06-01 00:00:00
abstract::The effect of the glutathione transferase P1-1 (GSTP1-1) targeting has been investigated in both sensitive (U-2OS) and cisplatin-resistant (U-2OS/CDDP4 μg) human osteosarcoma cell lines. Despite the different enzyme's content, inhibition of GSTP1-1 by 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) causes the...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05295k
更新日期:2012-04-01 00:00:00
abstract::Protein-adsorptive properties are a key feature of membranes used for haemodialysis treatment. Protein adsorption is vital to the biocompatibility of a membrane material and influences membrane's performance. The object of the present study is to investigate membrane biocompatibility by correlating the adsorbed proteo...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05393d
更新日期:2012-04-01 00:00:00
abstract::Deciphering functional interactions between proteins is one of the great challenges in biology. Sequence-based homology-free encoding schemes have been increasingly applied to develop promising protein-protein interaction (PPI) predictors by means of statistical or machine learning methods. Here we analyze the relatio...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05427b
更新日期:2012-04-01 00:00:00
abstract::The protein kinase C (PKC) family of serine/threonine kinases is an attractive drug target for the treatment of cancer and other diseases. Diacylglycerol (DAG), phorbol esters and others act as ligands for the C1 domain of PKC isoforms. Inspection of the crystal structure of the PKCδ C1b subdomain in complex with phor...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05452c
更新日期:2012-04-01 00:00:00
abstract::Insights into the structure and dynamics of modular polyketide synthases (PKS) are essential for understanding the mechanistic details of the biosynthesis of a large number of pharmaceutically important secondary metabolites. The crystal structures of the KS-AT di-domain from erythromycin synthase have revealed the re...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05425f
更新日期:2012-04-01 00:00:00
abstract::Renal cell carcinoma (RCC), the most common neoplasm affecting the adult kidney, is characterised by heterogeneity of histological subtypes, drug resistance, and absence of molecular markers. Two-dimensional difference gel electrophoresis (2-D DIGE) technology in combination with mass spectrometry (MS) was applied to ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05390j
更新日期:2012-04-01 00:00:00
abstract::To improve the performance of nanostructured calcium carbonate in gene delivery, a hydrophilic polysaccharide, alginate, was added to calcium carbonate co-precipitation systems to form alginate/CaCO(3)/DNA nanoparticles. The size and ζ-potential of the nanoparticles were measured by a zetasizer. Due to the existence o...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05337j
更新日期:2012-03-01 00:00:00
abstract::Sequence specific binding of DNA and RNA is of fundamental importance in the regulation of cellular gene expression. Because of their modular structure repeat domain proteins are particularly well suited for these processes and have been widely adopted throughout evolution. Detailed biochemical and structural data has...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c2mb05392f
更新日期:2012-03-01 00:00:00
abstract::Herein, we demonstrate that the bacterial signaling molecule, c-di-GMP, can enhance the peroxidation of hemin when proflavine is present. The c-di-GMP-proflavine-hemin nucleotidezyme can oxidize the colorless compound 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ABTS, to the colored radical cation ABTS˙(+) ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb05430b
更新日期:2012-03-01 00:00:00
abstract::The adaptation of the cellular network to functional changes, timing and patterning of gene expression is regulated by binding of transcription factors to gene regulatory elements, which in turn depends on co-occurring histone modifications. These two layers influence each other, enabling a further level of regulatory...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05363a
更新日期:2012-02-01 00:00:00
abstract::Complex signalling systems have evolved in multicellular organisms to enable cell-to-cell communication during growth and development. In plants, cell communication via the extracellular matrix (apoplast) controls many processes vital for plant survival. Secretion of ATP into the extracellular matrix is now recognised...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c1mb05278k
更新日期:2012-02-01 00:00:00
abstract::Disordered regions within proteins have increasingly been associated with various cellular functions. Identifying the specific roles played by disorder in these functions has proved difficult. However, the development of reliable prediction algorithms has expanded the study of disorder from a few anecdotal examples to...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c1mb05235g
更新日期:2012-01-01 00:00:00
abstract::Over the past decade there has been a growing acknowledgement that a large proportion of proteins within most proteomes contain disordered regions. Disordered regions are segments of the protein chain which do not adopt a stable structure. Recognition of disordered regions in a protein is of great importance for prote...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c1mb05207a
更新日期:2012-01-01 00:00:00
abstract::Proteins are dynamic creatures. Intrinsically disordered proteins (IDPs) function as multiplicity of structures and their activities can only be described by stochastic structure-function relationships. In their complex forms, however, IDPs were thought to lose their plasticity and behave similarly to globular protein...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c1mb05234a
更新日期:2012-01-01 00:00:00
abstract::New-type oseltamivir-resistant H1N1 influenza viruses have been a major threat to human health since the 2009 flu pandemic. To resolve the drug resistance issue, we aimed to identify a new type of inhibitors against H1 from traditional Chinese medicine (TCM) by employing the world's largest TCM database () for virtual...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05320e
更新日期:2011-12-01 00:00:00
abstract::The pro-inflammatory cytokines interleukin 1 (IL-1) and 6 (IL-6) are crucially involved in the regulation of a multitude of physiological processes, in particular coordinating the immune response upon bacterial infection and tissue injury. Both interleukins induce complex signalling cascades and trigger the production...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05261f
更新日期:2011-12-01 00:00:00
abstract::4-Aminoantipyrine (AAP) is scarcely administered as an analgesic drug because of the potential side effects. The residue of AAP in the environment possesses a potential threat to human health. In this article, the binding mode of AAP with the important antioxidant enzyme catalase (CAT) was investigated using spectrosc...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05271c
更新日期:2011-11-01 00:00:00
abstract::A major mode of signal transduction in bacteria is the two-component system, which involves phosphorylation of an output-generating receiver protein by a signal-sensing histidine kinase. This differs from the more common one-component system--where both signal sensing and output generation are performed by the same pr...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05260h
更新日期:2011-11-01 00:00:00
abstract::Within systems biology there is an increasing interest in the stochastic behavior of genetic and biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous time Markov chain (CTMC). In this paper we consider the stochastic properties ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05086a
更新日期:2011-10-01 00:00:00
abstract::High levels of DNA and RNA released by apoptotic and necrotic cells circulate in the blood of cancer patients. In the present study we determined the applicability of the quantification of nucleic acids and their genetic alterations as minimally invasive tool for breast cancer screening. The relative concentrations of...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05197k
更新日期:2011-10-01 00:00:00
abstract::Rule-based modeling provides a means to represent cell signaling systems in a way that captures site-specific details of molecular interactions. For rule-based models to be more widely understood and (re)used, conventions for model visualization and annotation are needed. We have developed the concepts of an extended ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05077j
更新日期:2011-10-01 00:00:00
abstract::Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. Thus, novel molecular markers that enable non-...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05029j
更新日期:2011-09-01 00:00:00
abstract::We explain that part of the reduction in the parameter uncertainties in the computations of Apgar et al. (Mol. Biosyst. 2010, 6, 1890-900) is due to a greatly increased number of effective data points. ...
journal_title:Molecular bioSystems
pub_type: 评论,信件
doi:10.1039/c1mb05046j
更新日期:2011-08-01 00:00:00
abstract::Diabetic retinopathy (DR) is a serious microvascular syndrome of diabetes, and is one of the most frequent causes of blindness in the world. It has three progressive stages with complex metabolic deregulations in the holistic system of Western medicine. Chinese medicine classifies DR into two different syndrome types;...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c0mb00341g
更新日期:2011-07-01 00:00:00
abstract::Peptidylarginine deiminase (PAD) catalyzes the posttranslational citrullination of selected proteins in a calcium dependent manner. The PAD4 isoform has been implicated in multiple sclerosis, rheumatoid arthritis, some types of cancer, and plays a role in gene regulation. However, the substrate selectivity of PAD4 is ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05089c
更新日期:2011-07-01 00:00:00
abstract::Secretagogin is a hexa EF-hand Ca(2+)-binding protein expressed in neuroendocrine, pancreatic endocrine and retinal cells. The protein has been noted for its expression in specific neuronal subtypes in the support of hierarchical organizing principles in the mammalian brain. Secretagogin has previously been found to i...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c0mb00349b
更新日期:2011-07-01 00:00:00
abstract::Biotin is an enzyme cofactor indispensable to metabolic fixation of carbon dioxide in all three domains of life. Although the catalytic and physiological roles of biotin have been well characterized, the biosynthesis of biotin remains to be fully elucidated. Studies in microbes suggest a two-stage biosynthetic pathway...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c1mb05022b
更新日期:2011-06-01 00:00:00
abstract::To identify an agent with specific activity against human lens epithelial cells (HLECs), we confirmed the presence of glucocorticoid receptors (GRs) and GR-α genes and evaluated whether GRs have a relationship with the apoptotic process in cultured HLECs. We also determined whether the inhibitor RU486 could rescue the...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05045a
更新日期:2011-06-01 00:00:00
abstract::Insight into the molecular mechanism of complex diseases is an important topic in the current bio-medical research. However, different from the single-gene disorders, high heterogeneity of many of the complex diseases prevents scientists from the exact understanding of the etiology. In this study, we used Myelodysplas...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c1mb05018d
更新日期:2011-06-01 00:00:00